“Tell me about yourself.”

If that question makes your stomach do little backflips, you’re not alone. No matter how confident you are in your nursing skills, interviews are a whole different ballpark.

Interview questions for oncology nurse applicants cover a range of topics, from your motivations for pursuing this specialty to your aptitude for complex symptom management. 

That’s why we’ve compiled our list of the top 11 oncology nurse interview questions. With a little preparation and a stellar oncology nurse resume to back you up, you can put your best foot forward and ace every upcoming interview.

#1. Understanding the Basics: “Tell Me About Your Oncology Nursing Experience”

Employers often want to gauge your hands-on experience in oncology nursing early in the interview. Oncology is a demanding speciality after all, and the interviewer will likely seek to gain insight into how you will perform (and have performed) in real-world clinical scenarios.

To answer this question, be prepared to provide an overview of your specific oncology nursing experience. Consider sharing details such as:

  • Past positions in oncology settings
  • Hands-on care you’ve provided to patients with cancer
  • Specialized training or certifications, such as Oncology Certified Nurse (OCN) credentials

If you have limited experience coming out of nursing school, offer to discuss coursework, clinical rotations, or independent learning you’ve undertaken. 

Pro Tip: While it’s not always easy, try to concisely summarize your professional history. Where possible, tailor your responses to the requirements from the job listing. This can help convey a sense of preparedness, confidence, and respect for the interviewer’s time.

#2. Discussing Your Approach: “How Do You Handle Stressful Situations in Oncology Nursing?”

Of all the oncology nurse interview questions, this one might be the most vague. At the same time, it’s extremely important given the emotionally (and physically) taxing nature of oncology. 

Seeing patients face life-altering diagnoses and uncertain outcomes day in and day out takes its toll on nurses. Generally, the purpose of this question is to help hiring managers determine whether you’re able to effectively manage the stress of caring for patients with cancer.

As for how you answer, it may be helpful to share specific challenges you’ve encountered. Walk through how you overcame the stress both in the moment and after hours. You might also want to mention any self-care practices you leverage to ensure you’re always providing the best possible care. These may include: 

  • Counseling
  • Debriefs with trusted colleagues
  • Personal hobbies, such as yoga or journaling

Often, employers seek out nurses with a balanced viewpoint—someone who is confident in their ability to work under pressure, while still acknowledging the challenges and reality of oncology nursing.

#3. Highlighting Your Skills: “What Specialized Oncology Skills Are You Proficient In?”

This question is pointed squarely at establishing your hard nursing skills. Here, interviewers want to confirm that you have the hands-on clinical capability essential for your oncology nursing duties.

This question presents an excellent opportunity to demonstrate your experience and training in tasks such as: 

  • Central line care and management 
  • Administration of IV chemotherapy and side effect medications
  • Blood component therapy
  • Radiation therapy
  • Biotherapy
  • Bone marrow transplant care
  • Symptom management

If applicable, be prepared to highlight specialized training in an oncology subspecialty, like hematology, neuro-oncology, or palliative care.

#4. Assessing Your Patient-Centric Approach: “How Do You Build Rapport with Oncology Patients?”

Building trust and rapport with patients is the heart and soul of oncology nursing. For this reason, employers want to know how you connect with patients and provide compassionate care.

When answering this question, open up about your approach to patient care, emphasizing empathy, active listening, and personalized care.  

Provide real examples of how you identify patient priorities, values, and preferences to guide care plan customization. Convey your dedication to providing comfort through evidence-based interventions so that you can ease suffering as you journey with patients through their cancer experiences.

#5. Handling Challenges: “Can You Share an Example of a Difficult Case in Oncology Nursing?”

This question assesses your problem-solving skills and ability to handle complex cases.

Choose an example that showcases your critical thinking, clinical skills, and emotional resilience. Explain the situation, the actions you took, and the outcome that followed.

#6. Showcasing Your Knowledge: “What Development in Oncology Treatment Has Piqued Your Interest and Why?”

Because cancer research is ongoing, treatments tend to evolve rapidly. Oncology nurses should stay informed on the latest medical developments to provide exceptional evidence-based care.

In your response to this question, aim to demonstrate a solid command over advancements in patient care. For example, you might try:

  • Mentioning resources you rely on to stay updated, like medical journals or professional nursing association publications
  • Discussing an emerging treatment option that recently caught your attention
  • Sharing your understanding of cutting-edge advancements in genomics, screening, or surgical innovations

Through your answers, try to emphasize the main purpose behind your dedication to lifelong learning: to help you better educate and support patients through emerging treatment options. 

#7. Team Dynamics: “How Do You Collaborate with Multidisciplinary Teams in Oncology?”

Oncology care often involves a team approach, so potential employers will naturally want to know how well you work in team settings.

Share examples of how you’ve collaborated with other healthcare professionals. Key qualities to highlight might include:

  • The importance of communication for quick and appropriate adjustments in patient care
  • Building trust and respect among a diverse range of medical professionals
  • Creating an inclusive, team-oriented environment that facilitates creative and patient-specific solutions

Showcasing these aspects of collaboration in an oncology setting can go a long way in demonstrating your suitability for the role.

#8. Addressing Professional Growth: “What Are Your Continuing Education Efforts in Oncology?”

Along with question six (“explain the latest developments in oncology treatments”), this oncology nurse interview question tests your commitment to ongoing learning. At the same time, how you answer can be a great opportunity to convey genuine passion for professional development.

Discuss any recent or ongoing education efforts, such as workshops you’ve attended, courses you’ve taken, or certifications you’ve earned. Then, dive a little deeper by briefly highlighting how this education has helped you elevate your quality of care. 

Pro Tip: If appropriate, inquire whether the facility offers reimbursed oncology specialty education or other opportunities such as a clinical ladder. Remember, interviews work both ways!

#9. Ethical Scenarios: “Describe How You Maintain Patient Confidentiality in Oncology Care”

Confidentiality is a cornerstone of healthcare, and oncology nurses are expected to balance caring for vulnerable patients while responsibly handling private information. 

So, to answer this question, you might describe how you adhere to standard safeguards, with practices such as: 

  • Setting appropriate passwords and privacy settings
  • Ensuring patient details are shared only with essential care providers
  • Interacting with patients and family discreetly in public waiting areas

Overall, aim to reassure the interviewer that you understand—and are committed to—maintaining HIPAA compliance and patient rights.

#10. Exploring Your Motivation: “What Motivates You to Pursue Travel Nursing in Oncology?”

While most common oncology nursing interview questions focus on skills and experience, this one allows you to shine a spotlight on your passion for the field of oncology and travel nursing.

When answering this question, share how and more importantly, why, you remain deeply driven to help guide patients across the country through difficult journeys.

Aim to express conviction that your clinical skills and experience can contribute meaningfully to filling care gaps nationwide as you float between short-staffed hospitals. Your dedication to making a tangible impact in diverse settings will no doubt leave a powerful impression.

#11. Demonstrating Adaptability: “How Would You Handle Sudden Changes in an Oncology Unit?”

Amidst volatile staffing shortages, policy updates, and other unforeseen disruptions common to the nursing field, the ability to adapt quickly is a crucial skill. Here are some suggestions on how to demonstrate adaptability to potential employers:

  • Highlight your ability to independently adjust your methods while upholding high standards of care—especially in situations with limited orientation resources. This is particularly valuable for oncology travel nursing roles.
  • At the same time, make it clear that you know how to ask pertinent questions to quickly grasp facility workflows and patient demographics on each new assignment.
  • Work through your approach to forming productive relationships with peers in new units. After all, fostering a collaborative environment from the start ensures uninterrupted patient care.

These answers show that you understand the challenges that are most common in modern healthcare settings. Plus, your ability to deal with these challenges demonstrates more than just flexibility—it also shows that you can steady yourself when things are chaotic, enabling you to give your very best to those counting on you.

Find the Oncology Nurse Role of Your Dreams With Host Healthcare

At Host Healthcare, we appreciate the daily courage and compassion of oncology nurses who work to make a difference in the lives of others. That’s why, in addition to offering interview advice and guidance, we also offer tailored job placement for exceptional travel nurses specializing in cancer care.

In fact, we provide exclusive access to oncology nurse jobs at renowned treatment centers and community hospitals nationwide so that you can be matched with your desired position and location. Plus, we handle all of the logistics—like pay package negotiation, reimbursements, license transfers, housing, and more—so that you can focus completely on providing thoughtful care.

Apply today to discover your perfect travel oncology nurse role with Host Healthcare.



Gentile, Venus. “Interview Tips: 10 Ways to Improve Interview Performance.” Monster. https://www.monster.com/career-advice/article/boost-your-interview-iq. Accessed December 29, 2023.

“25 Oncology Nurse Interview Questions and Answers.” Climb. Jan. 05, 2023. https://climbtheladder.com/oncology-nurse-interview-questions/. Accessed December 29, 2023.

“12 Oncology Nurse Skills: Definition and Examples.” Resume Cat. https://resumecat.com/career/oncology-nurse/skills. Accessed December 29, 2023.